Progress in pharmacodynamics and clinical studies of active components of Coix Seed (Semen Coicis) and its preparation - Kanglaite Injection (KLT)
نویسنده
چکیده
[ABSTRACT] Objective: A brief summary of recent progress in pharmacodynamics and clinical studies of active components of a TCM herbal medicine-Coix Seed and its preparation-Kanglaite Injection. Method: Based upon the references published at home and abroad, a review has been written on the pharmacological actions of Coix Seed and its preparation-Kanglaite Injection as well as its clinical studies. Results: Coix Seed and its preparation-Kanglaite Injection have antitumor and immunomodulating actions. [KEY WORDS] Coix Seed; Coix Lacryma-jobi; Active component; Preparation; Kanglaite (KLT); Pharmacodynamics; Antitumor action; Immunomodulation; Mechanism of action; Clinical studies
منابع مشابه
Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes
Many kinds of Chinese herb had been confirmed to have the character of anti-tumor, clinical reports about anti-tumor effects of Chinese herb had also been found in recent years, but most of the reports were focused on the clinical treatment of effectiveness for Chinese herb, on the other hand, review about Chinese herbal related with molecules on cancer-cell-apoptosis was seldom, many scientist...
متن کاملAntitumor effect of Kanglaite® injection in human pancreatic cancer xenografts
BACKGROUND Kanglaite® injection (KLT), with a main ingredient of Coix seed oil (a traditional Chinese medicine), has been widely used for cancer treatment in China. KLT has an inhibitory effect on many kinds of tumors and PI3K/Akt/mTOR signaling promotes cell survival, proliferation, and progression in cancer cells. Therefore, targeting this pathway may lead to the development of novel therapeu...
متن کاملKanglaite stimulates anticancer immune responses and inhibits HepG2 cell transplantation‑induced tumor growth.
Previous studies revealed that Kanglaite (KLT) exhibits antitumor and immunomodulatory activities. In the present study, we show that KLT treatment stimulated the immune response by increasing the number of T cells and natural killer (NK) cells in the blood of hepatocellular carcinoma (HCC) patients. Experiments in tumor-bearing mice were further designed in order to explore the effects of KLT ...
متن کاملClinical safety and efficacy of Kanglaite® (Coix Seed Oil) injection combined with chemotherapy in treating patients with gastric cancer.
OBJECTIVE To observe efficacy and side effects, as well as the impact on quality of life, of Kanglaite® (Coix Seed Oil) injections combined with chemotherapy in the treatment of advanced gastric cancer patiensts. METHOD A consecutive cohort of 60 patients were divided into two groups:the experimental group receiving Kanglaite® Injection combined with chemotherapy and the control group with ch...
متن کاملEffect of kanglaite on rat cytochrome P450.
CONTEXT Kanglaite (KLT) is an oily substance extracted from Coix lacryma-jobi Linn. (Cramineae) and has been proved to significantly improve the life span and quality of life of patients, when combined with chemotherapy, radiotherapy, or surgery. OBJECTIVE The purpose of this study was to find out whether KLT influences the effect on rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2B6, CYP2C9, ...
متن کامل